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Contraindicated (1)pentobarbital decreases amounts of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with powerful CYP3A4 inducers; these medicines minimize exposure to vandetanib by as many as 40%.pentobarbital will lessen the extent or outcome of eltrombopag by influencing hep

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